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Abstract #3478

The effect of dopaminergic drugs on reward prediction error and novelty processing in ADHD

Arjun Sethi 1 , Duncan Fowler 1 , Jessica Eccles 1 , Valerie Voon 2 , Hugo Critchley 1 , Mara Cercignani 1,3 , and Neil Harrison 1

1 Clinical Imaging Sciences Centre, Brighton & Sussex Medical School, Brighton, Sussex, United Kingdom, 2 Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, 3 Neuroimaging Laboratory, IRCCS Santa Lucia, Italy

Reward processing is dependent on dopaminergic activity, and it has been found to be affected in attention-deficit hyperactive disorder (ADHD). In this fMRI study, we seek to establish the effect of dopaminergic medication on novelty processing and reward prediction in ADHD. Patients were scanned twice, on their usual medication and on placebo. Participants engaged in a three-armed bandit task with novelty manipulation, and their choices were fitted by a temporal-difference learning model to estimate their prediction error. The activity of the ventral-striatum correlated with the prediction error, with preliminary evidence suggesting that such activity is modulated by the drug.

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