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Abstract #3469

Coexistence of enhanced and reduced Default Mode Network functional connectivity in Autism Spectrum Disorder

Letizia Casiraghi 1,2 , Chiara Pesola 3 , Fabrizio Esposito 4,5 , Carol Di Perri 2 , and Francesco Di Salle 4,5

1 Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, 2 Brain Connectivity Center, IRCCS C. Mondino, Pavia, Italy, 3 Department of Pediatrics and Child Neuropsychiatry, Sapienza University of Rome, Rome, Italy, 4 Department of Medicine and Surgery, University of Salerno, Baronissi (SA), Italy, 5 Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands

Autism Spectrum Disorder (ASD) is a neurodevelopmental disability with early onset and variable developmental trajectory. Nowadays a standard pattern of resting state Functional Connectivity (FC) alteration in ASD is not defined. We used ICA analysis on ASD and tipically developing subjects in order to test the influence of methodological choices on results and to investigate the differences in FC focusing on the Default Mode Network (DMN). Our study outlines the presence of both hypo- and hyper- FC within the DMN in ASD children.

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