Abstract #3468
A Resting-State Functional MRI Study in Violent Offenders with Schizophrenia
Yi Liao 1 , Xiaoqi Huang 1 , Junmei Hu 2 , Shiguang Li 1 , Xinyu Hu 1 , Qi Liu 1 , Lizhou Chen 1 , and Qiyong Gong 1
1
Huaxi MR Research Center, West China
Hospital of Sichuan University, Chengdu, Sichuan, China,
2
School
of Basic Science and Forensic Medicine, Sichuan
University, Chengdu, Sichuan, China
Low-frequency (0.01C0.08 Hz) fluctuations of the
blood-oxygenation-level-dependent signal in resting
state fMRI data are thought to reflect spontaneous
neural activity. We aim to perform a functional MRI to
detect the neural activity abnormalities in
schizophrenia patients with severely violent
behavior.Compared with the healthy control group, the
violent schizophrenia group demonstrated significant
ALFF reductions in various brain regions including the
left supplementary motor area, right paracentral lobule,
right thalamus and bilateral lingual gyrus. The
correlation of ALFF value and clinical and behavioral
scales were also conducted to explain the possible
mechanism underlying the special subgroup of
schizophrenia.
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