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Abstract #3468

A Resting-State Functional MRI Study in Violent Offenders with Schizophrenia

Yi Liao 1 , Xiaoqi Huang 1 , Junmei Hu 2 , Shiguang Li 1 , Xinyu Hu 1 , Qi Liu 1 , Lizhou Chen 1 , and Qiyong Gong 1

1 Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China, 2 School of Basic Science and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China

Low-frequency (0.01C0.08 Hz) fluctuations of the blood-oxygenation-level-dependent signal in resting state fMRI data are thought to reflect spontaneous neural activity. We aim to perform a functional MRI to detect the neural activity abnormalities in schizophrenia patients with severely violent behavior.Compared with the healthy control group, the violent schizophrenia group demonstrated significant ALFF reductions in various brain regions including the left supplementary motor area, right paracentral lobule, right thalamus and bilateral lingual gyrus. The correlation of ALFF value and clinical and behavioral scales were also conducted to explain the possible mechanism underlying the special subgroup of schizophrenia.

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