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Abstract #3466

Abnormal grey matter volume correlates with executive dysfunction in attention deficit hyperactivity disorder

Fei Li 1 , Ning He 2 , Yuanyuan Li 2 , Xiaoqi Huang 1 , Su Lui 1 , Lanting Guo 2 , and Qiyong Gong 1

1 Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China, 2 Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, China

Attention deficit hyperactivity disorder (ADHD) is characterized by age-inappropriate degrees of inattention, hyperactivity and impulsivity. The specific neuropsychological dysfunction underlying atypical brain structure remains poorly understood. ADHD patients often exhibit deficiencies in cognitive function. A link to executive dysfunction is central to models involving aberrant fronto-subcortical circuits; however, there has been much debate about what core deficit of brain structure might cause the impairments of ADHD. The aims of the present study were to define, in children and adolescents with ADHD, abnormalities of grey matter volume, and to explore the association between these alterations of brain structure and executive dysfunction.

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