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Abstract #3465

Brain Perfusion Differences in Autism Spectrum Disorders

Hua-Shan Liu* 1 , Gregory K. Bartley* 2 , John D. Herrington 2 , Benjamin E. Yerys 2 , John A. Detre 1 , and Robert T. Schultz 2

1 University of Pennsylvania, Philadelphia, PA, United States, 2 The Childrens Hospital of Philadelphia, Philadelphia, PA, United States

Autism Spectrum Disorder (ASD) is associated with abnormalities in brain areas associated with social information processing, including multiple temporal lobe regions. Although a number of ASD functional MRI studies have established decreased temporal lobe activation in contrasts of social information processing tasks versus control, almost no studies have examined region-specific differences in absolute cerebral blood flow (CBF). Pseudo-continuous ASL data were collected in 33 participants with ASD and 26 typically developing controls (TDCs). Decreased CBF in ASD was observed in multiple temporal lobe areas associated with social information processing including amygdala, fusiform gyrus, and superior temporal gyrus. These results suggest that core deficits in ASD may be mediated by deficits in blood flow in and around brain areas associated with social intelligence.

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