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Abstract #3464

Effective connectivity analysis of visual-motor network in patients with schizophrenia

Nathan L Hutcheson 1 , Karthik R Sreenivasan 2 , Gopikrishna Deshpande 2,3 , David M White 1 , and Adrienne C Lahti 1

1 Department of Psychiatry and Behavioral Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, United States, 2 AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, 3 Department of Psychology, Auburn University, Auburn, AL, United States

Previous studies about connectivity within the visual-motor network in patients with schizophrenia (SZ) has shown altered functional connectivity, but critical information regarding the directionality of these connections are unknown. In this study we utilized fMRI data analyzed using dynamic Granger causality to map the connectivity within the visual-motor network in healthy controls (HC) and SZ. We found that HC had stronger unidirectional connections projecting from the visual cortex to motor areas than SZ. Our results replicate previous connectivity findings in HC and show novel connectivity disruptions in SZ during the performance of a visual-motor paradigm.

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