Abstract #3460
Brain hyperactivation related to working memory in medication-naive boys with non-comorbid ADHD
Fei Li 1 , Yuanyuan Li 2 , Ning He 2 , Xiaoqi Huang 1 , Su Lui 1 , Lanting Guo 2 , and Qiyong Gong 1
1
Huaxi MR Research Center (HMRRC), Department
of Radiology, West China Hospital of Sichuan University,
chengdu, sichuan, China,
2
Department
of Psychiatry, West China Hospital of Sichuan
University, chengdu, sichuan, China
To our knowledge, the exploration of working
memory-related brain activation using the CN-BT has not
been previously reported in children and adolescents
with ADHD. In addition to having activation within the
sensory-motor pathways and the striato-cerebellum
circuit similar to that of healthy controls with related
visual-object and action cognitive strategies, the ADHD
patients also showed task-negative activation in the
fronto-cingulate-parietal network involved in working
memory. Additionally, the higher activation of the
bilateral globus pallidus and right hippocampus in ADHD
patients compared to healthy controls revealed an
important role in the pathophysiology of ADHD related to
working memory.
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