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Abstract #3461

Abnormal WM microstructural trajectories of autistic children from 2 to 7 years of age

Minhui Ouyang 1 , Hua Cheng 2 , Gaolang Gong 3 , Matt Mosconi 4,5 , John Sweeney 4,5 , Yun Peng 2 , and Hao Huang 1

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2 Beijing Children's Hospital, Capital Medical University, Beijing, China, 3 State key laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China, 4 Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States, 5 Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States

The majority of the studies using diffusion tensor imaging (DTI) to investigate the white matter (WM) integrity in the autistic brains have been focusing on the age range from mid-childhood to adolescence. In this study, we hypothesized that the growth trajectories of the microstructural metrics of WM tracts from 2 to 7 years of age is different between autistic and normal children, and these differences are widespread to limbic, commissural, association and project tract groups. To test these hypotheses, high quality DTI of totally 51 children was acquired and trajectories of DTI metrics of all WM voxels were examined.

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