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Abstract #3459

Altered white matter tract integrity as a potential endophenotype of schizophrenia: a sibling study using automatic tract-specific analysis of the whole brain

Chen-Hao Wu 1,2 , Yu-Jen Chen 2 , Yun-Chin Hsu 2 , Yu-Chun Lo 2 , Tzung-Jeng Hwang 3 , Hai-Go Hwu 3 , Chung-Ming Chen 1 , and Wen-Yih Isaac Tseng 1,2

1 Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, Taiwan, 2 Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Taiwan, 3 Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan, Taiwan

Alteration of white matter tract integrity was reported in siblings of schizophrenia patients in several studies using voxel-based analysis (VBA). Some studies suggested that tract-specific analysis (TSA) may be more specific and reliable than VBA. However, manual tractography, which is currently the main-stream approach, is time consuming and not feasible for analyzing whole brain tracts. In this study, we proposed a new method to perform tract-specific analysis over the whole brain, named tract-based automatic analysis (TBAA), using a diffusion spectrum imaging (DSI) template and a tract atlas. Using this method, we assessed the entire brain white matter tracts and searched for potential white matter tracts which could represent a possible endophenotype of schizophrenia. We hypothesized that the potential endophenotype of white matter tracts showed altered integrity in both patients and siblings, and the alteration had a gradation of differences from patients, siblings to contols.

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