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Abstract #3414

Normobaric oxygen treatment worsens Mild Traumatic Brain Injury

Lora Talley Watts 1 , Justin A. Long 1 , Jonathan Chemello 1 , Qiang Shen 1 , and Timothy Duong 1

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

Normobaric oxygen (NBO) increases brain oxygenation, thereby minimizing ischemia-like injury. The goal of this study was to investigate the neuroprotective effect of normobaric oxygen (NBO) following traumatic brain injury (TBI) as measured by lesion volume and functional outcome measures. This study demonstrates that NBO exacerbates lesion volume compared to air-treated animals associated with TBI. NBO did not worsen or improve behavioral outcome measures.

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