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Abstract #3413

Neuroprotective effects of Methylene Blue in Mild Traumatic Brain Injury

Lora Talley Watts 1 , Justin A. Long 1 , Jonathan Chemello 1 , Qiang Shen 1 , and Timothy Duong 1

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

Methylene blue (MB) has energy-enhancing and antioxidant properties. MB treatment has been shown to reduce neurobehavioral impairment in Parkinson's disease and in Alzheimers disease in animals. This study investigated the novel neuroprotective effect of MB on mild traumatic brain injury (TBI) as measured by lesion volume, histology, and functional outcome. We found that MB treatment minimized lesion volume and functional deficits compared to vehicle-treated animals. Immunohistological staining for neuronal degeneration corroborated MRI lesion volume and behavioral data. MB has an excellent safety profile and is clinically approved for other indications. MB clinical trials on TBI can thus be readily explored.

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