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Abstract #3412

Longitudinal Imaging of Cerebral Microhemorrhages Using Qualitative and Quantitative Susceptibility Imaging in Military Service Members with Traumatic Brain Injury

Wei Liu 1,2 , Karl Soderlund 3 , Tian Liu 4 , Justin S. Senseney 1,2 , Ping-Hong Yeh 1,2 , John Graner 1,2 , John Ollinger 1,2 , Jamie Harper 1,2 , David Joy 1,2 , Terrance R. Oakes 1,2 , Yi Wang 4 , and Gerard Riedy 1,2

1 National Intrepid Center of Excellence, Bethesda, Maryland, United States, 2 National Capital Neuroimaging Consortium, Bethesda, Maryland, United States, 3 Walter Reed National Military Medical Center, Bethesda, Maryland, United States, 4 Biomedical Engineering, Cornell University, New York, New York, United States

Cerebral microhemorrhages in combat-related TBI patients were characterized longitudinally using SWI and QSM. Both approaches demonstrated better conspicuity on majorities of the detected microhemorrhages relative to GRE. QSM demonstrated worse conspicuity than GRE in a small portion of the microhemorrhages. Both SWI and QSM showed strong trends to detect more microhemorrhages at baseline compared to follow-ups in TBI patients. For individual microhemorrhages, both the size of microhemorrhage and total magnetic susceptibility decreased significantly from baseline to follow-up scans, suggesting a continued subtle evolution of the hemosiderin blood products on a longer time frame than was previously believed.

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