Abstract #3411
Statistical analysis of structural and functional connectivity networks in patients with severe brain injury
Amy Kuceyeski 1 , Sudhin Shah 2 , Stephan Bickel 3 , Nicholas Schiff 2 , and Henning Voss 4
1
Radiology, Weill Cornell Medical College,
New York, NY, United States,
2
Neurology,
Weill Cornell Medical College, New York, NY, United
States,
3
Neurology, Albert Einstein College of
Medicine, New York, NY, United States,
4
Citigroup
Biomedical Imaging Center, Weill Cornell Medical
College, New York, NY, United States
The relationship between structural (SC), functional
connectivity (FC) and behavioral function is studied in
20 subjects with severe brain injury. We find that
global and not local SC network measures are
significantly different between patients and normals,
while FC networks show significantly different local,
and not global, measures when compared to normals. In
addition, we show that SC in subcortical regions and the
default mode network are correlated with behavioral
scores in patients. The discrepancy of SC and FC network
variation in patients versus normals may be due to the
relative plasticity of FC networks when compared to SC
networks.
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