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Abstract #3415

Altered functional connectivity in the brain default-mode network of earthquake survivors

Mingying Du 1 , Su Lui 1 , Keith Maurice Kendrick 2 , Xiaoqi Huang 1 , and Qiyong Gong 1

1 West China Hospital of Sichuan University, Chengdu, Sichuan, China, 2 School of Life Science and Technology, University of Electronic Science and Technology of China, sichuan, China

Little is known about the long-term impact of traumatic experience which may provide a better understanding of consequences of trauma. We have applied graph theory analysis of resting-state functional magnetic resonance imaging to explore longitudinally the progressive impact of severe stress on whole brain functional networks in physically healthy survivors of the Wenchuan earthquake within 25 days and 2-years after the earthquake. Results show that while functional connectivity changes three weeks after the disaster involved both frontal-limbic-striatal and default-mode networks, at the 2-year follow up only changes in the latter persisted, despite complete recovery from high initial levels of anxiety.

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