Abstract #3399
Lesion Effects on cerebellar peduncles DTI metrics in MS patients
Salem Hannoun 1,2 , Francoise Durand-Dubief 2,3 , Danielle Ibarrola 4 , Michele Cavallari 5 , Christian Confavreux 3 , Francois Cotton 2,6 , Charles RG Guttmann 5 , and Dominique Sappey-Marinier 2,4
1
OFSEP, University of Lyon, Bron,
Rhones-Alpes, France,
2
CREATIS,
University of Lyon, Lyon, Rhones-Alpes, France,
3
Service
de Neurologie A, Pierre Wertheimer Neurological
Hospital, Bron, Rhones-Alpes, France,
4
CERMEP-Imagerie
du Vivant, Bron, Rhones-Alpes, France,
5
Brigham
Hospital, Harvard University, Boston, Massachusetts,
United States,
6
Service
de Radiologie, Centre Hospitalier Lyon-Sud, Lyon,
Rhones-Alpes, France
The goal of this cross-sectional study was to
investigate the relative contribution of cerebellar
peduncles microstructural integrity in determining
disability in two groups of Multiple Sclerosis patients,
with (WL) and without (NL) lesions, in the three
cerebellar peduncles. Our results demonstrated
significant alterations of diffusivity in the cerebellar
white matter regions of all Multiple Sclerosis patients.
These findings suggest the presence of microstructural
damage of the cerebellum that probably contributed to
the decreased motor and cognitive performances observed
in Multiple Sclerosis patients, and particularly in
patients with cerebellar peduncles lesions.
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