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Abstract #3400

Test-retest reliability of whole brain myelin water fraction analysis using a spatially constrained multi-Gaussian algorithm on spiral T2 relaxometry data at 3 Tesla

Sneha Pandya 1 , Thanh D. Nguyen 1 , Mitchell A. Cooper 1 , Eve LoCastro 1 , Michael Dayan 1 , Susan A. Gauthier 2 , and Ashish Raj 1

1 Department of Radiology, Weill Cornell Medical College, New York, NY, United States, 2 Department of Neurology, Weill Cornell Medical College, New York, NY, United States

Eleven healthy volunteers were scanned twice within the same session at 3T using a whole brain fast T2prep 3D spiral sequence. Myelin water fraction (MWF) maps were extracted from these spirals using an automated processing pipeline with the spatially constrained multi-Gaussian algorithm. The inter-scan repeatability for the test-retest reliability of whole brain MWF maps was assessed. The whole brain MWF maps were highly repeatable between the two scans with the mean correlation coefficient R = 0.91 0.03 and mean relative mean squared difference = 3.5 1.5% (n=11). Bland-Altman plots reveal a negligible bias within narrow limits of agreement.

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