Meeting Banner
Abstract #3371

Distant Effects of Multiple Sclerosis Lesions: A weekly follow-up

Gabriel KOCEVAR 1 , Salem HANNOUN 1,2 , Franoise DURAND-DUBIEF 1,3 , Jean-Amede ROCH 4 , Franois COTTON 1,4 , and Dominique SAPPEY-MARINIER 1,5

1 CREATIS, UMR5520 & U1044 INSERM, University of Lyon, Lyon, Rhone-Alpes, France, 2 OFSEP, University of Lyon, Bron, Rhone-Alpes, France, 3 Service de Neurologie A, Hpital Neurologique, Bron, Rhone-Alpes, France, 4 Service de Radiologie, Centre Hospitalier Lyon-Sud, Lyon, Rhone-Alpes, France, 5 CERMEP - Imagerie du Vivant, Bron, France

White matter lesions could lead to neurodegeneration along the fibers. This study proposes to evaluate white matter lesions effects on distant regions based on weekly longitudinal follow-up. This longitudinal analysis highlighted the ability of DTI to quantify and monitor underlying pathological mechanisms occurring in the lesion, and to a lesser extent, in the normal appearing WM. Significant correlation between lesion and CC L1, may suggest an axonal degenerative process occurring along the fiber. Furthermore, fiber tracking may constitute a new tool to monitor distant effects of lesions, and therefore better understand the relation between inflammatory events and neurodegenerative processes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here