Abstract #3363
1H MRS for in vivo detection of 2-hydroxyglutarate in brain tumors at 1.5T: A numerical simulation study
Changho Choi 1
1
Advanced Imaging Research Center, UT
Southwestern Medical Center, Dallas, Texas, United
States
2-Hydroxyglutarate (2HG) is produced in gliomas with IDH
mutations. Given the diagnostic and prognostic value of
2HG and the high availability of 1.5T MR scanners in
clinics, the capability of detecting 2HG at 1.5T in-vivo
is of high significance. Here we report a computer
simulation study for 2HG detection at 1.5T. Synthetic
spectra of 15 metabolites with random noises were
generated at TE = 20, 66, and 143 ms for various 2HG
concentrations and the 2HG detectability was examined
with spectral fitting. The 2HG concentrations were well
reproduced, suggesting that in-vivo detection of 2HG is
highly feasible at 1.5T.
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