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Abstract #3362

Different spatial distribution between GCB and non-GCB PCNSL revealed by MR group analysis of 100 cases.

Manabu Kinoshita 1,2 , Takashi Sasayama 3 , Yoshitaka Narita 4 , Fumio Yamashita 5 , Atsushi Kawaguchi 6 , Naoya Hashimoto 2 , and Toshiki Yoshimine 2

1 Neurosurgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka, Japan, 2 Neurosurgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 3 Neurosurgery, Kobe University Graduate School of Medicine, Hyogo, Japan, 4 National Cancer Center Hospital, Neurosurgery and Neuro-Oncology, Tokyo, Japan, 5 Division of Ultrahigh Field MRI, Iwate Medical University, Iwate, Japan, 6 Biostatistics Center, Kurume University, Fukuoka, Japan

MR based group analysis is a powerful tool to elucidate pathological conditions in the brain that are challenging to be revealed by single subject analysis. The presented research aimed to elucidate special distribution characteristics of primary central nervous system lymphoma (PCNSL) within the brain with respect to its molecular marker expression patterns. GCB lymphomas located at around the posterior portion of the white matter surrounding the lateral ventricles and the cerebellum around the 4th ventricle, while non-GCB lymphomas tended to occupy the anterior portion of the white matter surrounding the lateral ventricles. This is the very first report that addresses phenotypical and spatial distributional difference between GCB and non-GCB PCNSL.

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