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Abstract #3330

Reproducibility and Sensitivity of Quantitative Magnetization Transfer Imaging in Longitudinal Assessment of Spinal Cord Injuries of Monkey

Feng Wang 1,2 , Ke Li 1,2 , Huixin Qi 3 , Arabinda Mishra 1 , Chaohui Tang 1 , Daniel Gochberg 1,2 , Li Min Chen 1,2 , and John C. Gore 1,2

1 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 2 Radiology Department, Vanderbilt University, Nashville, TN, United States, 3 Psychology Department, Vanderbilt University, Nashville, TN, United States

We optimized acquisition schemes for in vivo quantitative magnetization transfer (qMT) imaging and evaluated the reproducibility and sensitivity of qMT parameters for assessing spinal cord injuries (SCI) of anesthetized squirrel monkeys. The results provided robust and sensitive parameters to the formation of abnormalities around the lesion site after SCI. Those qMT parameters were highly correlated to measures of T1, ADC and MTRasym. MRI findings were in agreement with spinal cord tissue histology. This study can help us understand the formation of tumor, cyst or edema, demyelination, inflammation and gliosis during the healing progress after unilateral dorsal column lesion at cervical spinal cord level.

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