Abstract #3331
Quantitative MT provides evidence for neuroinflammation in the brain following Interferon- treatment
Nicholas G Dowell 1 , Neil A Harrison 1 , Ella Cooper 1 , and Mara Cercignani 1
1
Clinical Imaging Sciences Centre, Brighton
and Sussex Medical School, Falmer, Brighton and Hove,
United Kingdom
There is growing evidence that neuroinflammation has a
pathogenic role in psychiatric illness, although the
presence of subtle inflammation in the brain has not
been widely studied. Inflammation can be induced by the
administration of a cytokine such as interferon-alpha
and although this inflammation is likely to be present
in the brain, conventional MR approaches are not
sensitive to such subtle changes. In this study, we use
qMT to show that the MT transfer rate (kf) is sensitive
to changes in the brain following inflammation with
interferon and this may enable the study of the
pathogenesis of psychiatric illnesses such as
schizophrenia and depression.
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