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Abstract #3329

Novel Quantitative Magnetization Transfer (qMT) of the Human Optic Nerve in vivo.

Alex K Smith 1,2 , Richard D Dortch 2,3 , and Seth A Smith 2,3

1 Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2 Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3 Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

Optic nerve damage is related to the eventual development of MS, and often results in permanent, visual dysfunction. While qMT has been used to evaluate tissue microstructure in the brain and spinal cord, studies in the optic nerve have been limited due to poor contrast between the optic nerve and surrounding tissue. The Dixon method has been used for fat/water separation; however, it has never been applied to the optic nerve, or for qMT imaging. Here we apply novel qMT utilizing Dixon fat/water separation for accurate quantification of the pool size ratio in the human optic nerve in vivo.

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