Abstract #3321
31P Magnetic Resonance Spectroscopy and amide proton transfer-Chemical Exchange Saturation Transfer based probes for intracellular pH measurements at 7 tesla
Vitaliy Khlebnikov 1 , Jannie Wijnen 1 , Michel Italiaander 2 , Alex Bhogal 1 , Hans Hoogduin 1 , and Dennis Klomp 1
1
Department of Radiology, University Medical
Center Utrecht, Utrecht, Netherlands,
2
MR
Coils BV, Drunen, Netherlands
Poor spatial resolution is the main limitation of
phosphorous-31 MRS for intracellular pH (pHi)
quantification. A new method for measuring pHi with high
spatial resolution is desired. The feasibility of amide
proton transfer (APT) pHi measurements was already
demonstrated. However, pHi sensitivity of APT was not
addressed. To the end, we therefore propose a setup that
combines accurate but low resolution 31P MSR with high
resolution chemical exchange saturation transfer (CEST)
in the quantification of pHi, using the higher spectral
resolution and SNR of 7T. The findings of the study
suggest that APT contrast is highly pHi sensitive and
can be quantified using 31P MRS in the same subject.
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