Abstract #3320
Validation of APT as a measure of pH by 31P in a piglet model of HIE
Marilena Rega 1 , Francisco Torrealdea 1 , Alan Bainbridge 2 , David L Price 2 , Magdalena Sokolska 1 , Kevin Broad 3 , Go Kawano 3 , Mojgan Ezatti 3 , Igor Fierrens 3 , Aaron Oliver-Taylor 1 , Christina Uria-Avellanal 3 , Simon Walker-Samuel 4 , David L Thomas 1 , Nikola Robertson 3 , and Xavier Golay 1
1
Institute of Neurology, UCL, London, London,
United Kingdom,
2
UCLH,
London, United Kingdom,
3
Institute
for woman's health, UCLH, London, United Kingdom,
4
Centre
for Advance Biomedical Imaging, UCL, London, United
Kingdom
The present work demonstrates the use of APT-MRI as a
measure of local pH changes in a model of Hypoxia
ischemia insult in the piglet brain. 31P MRS confirms
the pH response seen with APT. This work highlights the
advantage of spatial information from local pH
variations, which may vary across the brain. This
technique has the potential to be used in the clinic to
map local pH changes and assess treatment effectiveness
in newborns suffering from asphyxiation during birth.
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