Meeting Banner
Abstract #3319

Intracellular pH Measurement by AACID-CEST MRI at 9.4T: Imaging brain tumor-selective acidification by lonidamine

Nevin McVicar 1,2 , Alex X Li 2 , Susan Meakin 2,3 , and Robert Bartha 1,2

1 Medical Biophysics, University of Western Ontario, London, Ontario, Canada, 2 Robarts Research Institute, Ontario, Canada, 3 Biochemistry, University of Western Ontario, London, Ontario, Canada

Lonidamine is an anticancer drug that selectively decreases intracellular pH in tumor cells. A ratiometric CEST approach called amine/amide concentration independent detection (AACID) was recently developed to measure absolute intracellular pH in vivo using MRI. In this study, we produce pH maps before and ~1-2 hour after injection of lonidamine and then immediately post mortem in a brain tumor mouse model. Results show that lonidamine exclusively decreases tumor intracellular pH by ~0.2 pH units and AACID is capable of mapping local changes in brain tumor pH in vivo.

This abstract and the presentation materials are available to members only; a login is required.

Join Here