Meeting Banner
Abstract #3318

A comparison of iopromide and iopamidol, two acidoCEST MRI contrast agents that measure tumor extracellular pH

Brianna F. Moon 1 , Liu Qi Chen 2 , Peilu Liu 2 , Christine M. Howison 1 , Kyle M. Jones 1 , and Mark D. Pagel 1,2

1 Department of Biomedical Engineering, University of Arizona, Tucson, Arizona, United States, 2 Department of Chemistry & Biochemistry, University of Arizona, Tucson, Arizona, United States

AcidoCEST MRI contrast agents (CA) iopromide (UltravistTM, Bayer Health Care, Inc.) and iopamidol (IsovueTM, Bracco Imaging, Inc.) show similar imaging characteristics with respect to excitation pulse, method of frequency encoding, and effects CA concentration, T1 time , and temperature. Iopromide shows better CEST dynamic range for measuring pH, while iopamidol shows better precision. Both contrast agents can be used to measure extracellular pH in vivo.

This abstract and the presentation materials are available to members only; a login is required.

Join Here