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Abstract #3322

The Amine CEST Feature as a Biomarker of Apoptosis

Martin Durant 1 , Sharon Portnoy 2 , Kimberly L Desmond 1 , Claudia Dziegielewski 2 , Martin P. Stanisz 2 , Anne L Martel 1,2 , and Greg J. Stanisz 1,2

1 Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, 2 Sunnybrook Research Institute, Toronto, Ontario, Canada

Apoptosis was investigated using Chemical Exchange Saturation Transfer (CEST). Samples of Acute Myeloid Leukemia cells were scanned at 7T, half treated with cisplatin, and half as the untreated control, with CEST offset frequencies -3000-3000Hz. The most notable difference is seen in the Amine feature (~2ppm offset), which is clearly seen in the control, but absent in the treated spectra. A simple "relative area" measure is used to quantify the change, which is highly significant. Some speculation on the possible causes is given. CEST spectroscopy thus may enable monitoring of response to agents such as cisplatin.

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