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Abstract #3292

Accelerated CEST-MRI of in vivo human brain using Compressed Sensing at 3T: a pilot study

Qinwei Zhang 1 , Yanjie Zhu 2 , Jing Yuan 1,3 , Shuzhong Chen 1 , Deyond Siu 1 , Min Deng 1 , Yi-Xiang J Wang 1 , and Dong Liang 2

1 Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, 2 Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Shenzhen, Guangdong, China, 3 CUHK Shenzhen Research Institute, Shenzhen, Guangdong, China

CEST-MRI is a promising molecular imaging technique while suffers from long scan time and low contrast-to-noise ratio (CNR) in clinical use. In this study, we proposed the use of compressed sensing (CS) to accelerate the CEST-MRI at 3T. Full-sampled CEST-MRI data of in vivo human brain were retrospectively under-sampled and reconstructed up to a reduction factor of four. The CS-reconstructed magnetization transfer ratio asymmetry and ΔB0 maps showed excellent consistency with those using normal reconstruction from full samples. Goodness-of-fit of the CS-reconstructed Z-spectrum fitting was even better than the fully sampled one.

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