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Abstract #3293

Prospective motion correction with EPI volume navigators for chemical exchange saturation transfer (CEST) imaging

Robert Frost 1 , Aaron T. Hess 2 , Nicholas P. Blockley 1 , Yee Kai Tee 3 , Michael A. Chappell 1,3 , M. Dylan Tisdall 4,5 , Andre J. W. van der Kouwe 4,5 , and Peter Jezzard 1

1 FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2 Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 3 Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 4 A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 5 Radiology, Harvard Medical School, Boston, MA, United States

Chemical exchange saturation transfer (CEST) is a promising technique for treatment planning in acute stroke. However, when using single-slice measurements, the CEST acquisition is particularly susceptible to through-plane patient motion, which cannot be corrected in post-processing with 2D image registration. Here we used prospective motion correction with 3D EPI volume navigators to update the position of the imaging slice in real time, with no increase in scan duration and minimal effect on the image contrast. Maps of magnetization transfer asymmetry were compared in cases of no motion and deliberate motion to demonstrate the improvement in data quality with prospective motion correction.

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