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Abstract #3166

Indirect MRI Detection of Myelin Water Based on Water Exchange Properties

Xu Jiang 1 , Peter van Gelderen 1 , Jacco A de Zwart 1 , and Jeff H Duyn 1

1 AMRI, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States

A novel approach is presented to indirectly image brain myelin content. The proposed method is based on a pulsed saturation transfer experiment, in which water with short T 2 (including myelin water) is selectively saturated, after which the delayed effect on long T 2 water is studied. Experiments performed at 7T confirm sensitivity and specificity of the method.

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