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Abstract #3161

Bicarbonate as a theragnostic CEST agent for glioma models

Francisco Torrealdea 1 , Marilena Rega 1 , Joanne Lau 1 , Jessica Broni 1 , Sebastian Brandner 1 , Simon Walker-Samuel 2 , David L Thomas 1 , and Xavier Golay 1

1 Institute of Neurology, UCL, London, London, United Kingdom, 2 Centre for Advance Biomedical Imaging, UCL, London, London, United Kingdom

Upregulated aerobic glycolysis in tumours causes acidic extracellular pH. Changes in pH can be detected in-vivo by CEST MRI. The goal of this study is to assess the CEST signal response of brain gliomas following the administration of an intra-peritoneal (IP) bolus of sodium bicarbonate. This preliminary study shows the potential of bicarbonate as a theragnostic CEST agent for the treatment and early assessment of gliomas.

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