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Abstract #3160

Monitoring extracelluar pH, spatial heterogeneity and contrast agent uptake in lymphoma tumor growth with acidoCEST MRI

Liu Qi Chen 1 , Christine M. Howison 2 , Amanda F. Baker 3 , and Mark D. Pagel 2

1 Chemistry & Biochemistry, University of Arizona, Tucson, AZ, United States, 2 Biomedical Engineering, University of Arizona, Tucson, AZ, United States, 3 The University of Arizona Cancer Center, University of Arizona, Tucson, AZ, United States

Extracelluar pH (pHe) is a hallmark for tumor microenvironment. A non-invasive MRI method, term acidoCEST MRI, was used to accurately measure pHe and assess tumor acidosis. The pixel-wise pHe mapping allows us to access spatial heterogeneity and also contrast agent uptake. We have applied acidoCEST MRI to monitor effects of tumor growth in lymphoma tumor model, Raji, Ramos and Granta519. Our results showed mildly acidic pHe in all 3 tumor models. Granta519 pHe decreased over the course of 3 weeks. The % contrast agent uptake evaluated using acidoCEST MRI correlated with ex vivo VEGF-A score.

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