Abstract #3159
Simultaneously Measuring Glycogen and Lipid Levels Using Localized CEST Spectroscopy at 3T
Stephen J Bawden 1 , Olivier Mougin 1 , Karl Hunter 2 , Luca Marciani 3 , and Penny Gowland 1
1
SPMMRC, University of Nottingham,
Nottingham, United Kingdom,
2
Unilever
Discover, Bedford, United Kingdom,
3
NDDC
Biomedical Research Unit, University of Nottingham,
Nottingham, United Kingdom
Glycogen and Lipid levels are measured simultaneously
using localised GlycoCEST proton MRS. Phantoms with
glycogen, glucose and coconut milk were scanned using
frequency stepped pre-saturation pulses and PRESS
localization for MRS acquisition. Individual spectra
were averaged in saturated and non-saturated regions to
determine lipid-to-water peak ratios, and the asymmetry
of off-resonance saturation water peak heights used to
determine the CEST effect. This sequence was tested in
vivo in the liver for varying off resonance saturations,
and for varying pulse powers. This pilot study offers a
promising new technique for reducing study time and
costs whilst simultaneously measuring multiple metabolic
pathways.
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