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Abstract #3158

Spin-lock MRI of glucose and deoxyglucose concentration changes in brain

Tao Jin 1 , Hunter Mehrens 1 , and Seong-Gi Kim 1,2

1 Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2 Center for Neuroscience Imaging Research, Department of Biological Sciences, SKKU, Suwon, Korea

With chemical exchange dependent saturation transfer (CEST) MRI, recent animal studies administering natural D-glucose demonstrated results comparable to PET, and showed wide potential applications in diseases such as cancer. However, this gluco-CEST approach has low sensitivity, low temporal resolution, and is highly susceptible to B0 shifts. Furthermore, the CEST signal is strongly affected by other relaxation effects such as T1, T2 and magnetization transfer, and lacks a reliable means to quantify glucose concentration. In this study we showed that spin-lock MRI is highly sensitive to the administration of D-glucose and 2-deoxy-D-glucose, and is able to quantify concentration changes.

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