Abstract #3162
Generating Quantitative pH Maps in Hyper-acute Stroke Patients Using Amide Proton Transfer (APT) Imaging
Yee Kai Tee 1 , George Harston 2 , Nicholas Blockley 3 , Thomas Okell 3 , Jacob Levman 1 , Martino Cellerini 4 , Fintan Sheerin 4 , Peter Jezzard 3 , James Kennedy 2 , Stephen Payne 1 , and Michael Chappell 1
1
Department of Engineering Science, Institute
of Biomedical Engineering, University of Oxford, Oxford,
Oxfordshire, United Kingdom,
2
Acute
Stroke Programme, Radcliffe Department of Medicine,
University of Oxford, Oxfordshire, United Kingdom,
3
FMRIB,
Nuffield Department of Clinical Neurosciences,
University of Oxford, Oxfordshire, United Kingdom,
4
Department
of Neuroradiology, Oxford University Hospitals NHS
Trust, Oxfordshire, United Kingdom
Amide proton transfer (APT) imaging is a variant of
chemical exchange saturation transfer (CEST) that has
potential for assessing ischemic tissue at risk for
infarction. In this study, APT data in healthy subjects
and hyper-acute stroke patients within 6 hours of onset
were acquired. A quantitative model-based analysis,
where the modified Bloch equations were fitted to
measured data using Bayesian algorithm, was used to
quantify the APT effect. Based on the quantified APT
effect and a previously published pH versus amide proton
exchange rate relationship, quantitative pH maps in
healthy subjects and stroke patients were generated.
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