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Abstract #3152

Multi-pool CEST imaging of glioblastoma at 7 T

Jan-Eric Meissner 1 , Johannes Windschuh 1 , Moritz Zaiss 1 , Daniel Paech 2,3 , Alexander Radbruch 2,3 , and Peter Bachert 1

1 Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 2 Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany, 3 Neurooncologic Imaging, Department of Radiology, German Cancer Research Center, Heidelberg, Germany

Chemical Exchange Saturation Transfer (CEST) enables indirect imaging of metabolites in vivo via magnetization transfer between exchanging protons of functional groups and water protons. We propose and evaluate a 2D-CEST sequence with high spectral sampling which allows for pixel-wise detection and separation of NOE-, amides-, and amine-mediated CEST effects and MT simultaneously by the use of a multi Lorentzian fit. Especially isolated amide and NOE mapping allowed insights into glioblastoma substructure.

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