Abstract #3151
Amide Proton Transfer Imaging of the Head and Neck at 3T: A Feasibility Study and preliminary results
Jing Yuan 1 , Ann D King 1 , Shuzhong Chen 1 , Kunwar S Bhatia 1 , Qinwei Zhang 1 , Tom Wing Cheung Yuen 1 , Yi-Xiang J Wang 1 , David Ka Wai Yeung 1 , Juan Wei 2 , and Jinyuan Zhou 3
1
Imaging and Interventional Radiology, The
Chinese University of Hong Kong, Shatin, NT, Hong Kong,
2
Philips
Research China, Shanghai, China,
3
Department
of Radiology, Johns Hopkins University School of
Medicine, Baltimore, Maryland, United States
This study for the first time explored the use of
APT-MRI for the head and neck (HN) at 3T, which is
challenging due to tissue heterogeneity, pronounced
susceptibility and various motions. We successfully
demonstrated the feasibility of APT-MRI for the HN at
clinical field strengths by adopting various approaches
for image acquisition and data processing to mitigate
the technical challenges. Z-spectra and of magnetization
transfer ratio asymmetry of HN tissues were recorded.
Preliminary results of APT-MRI on HN tumor patients
showed that APT effect would be promising to be used as
a sensitive biomarker for tumor delineation and
characterization.
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