Abstract #3153
High Throughput Screening of Contrast Agents by Ultrafast CEST Imaging
Xiang Xu 1,2 , Jiadi Xu 1,2 , Nirbhay N. Yadav 1,2 , Craig K. Jones 1,2 , Michael T. McMahon 1,2 , Alexej Jerschow 3 , and Peter C. M. van Zijl 1,2
1
Radiology Department, Johns Hopkins
University School of Medicine, Baltimore, MD, United
States,
2
F.
M. Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Research Institute, Baltimore, MD,
United States,
3
Chemistry
Department, New York University, New York, NY, United
States
Recently we reported an ultrafast method to obtain a
Z-spectrum over a large range of frequency offsets from
only two signal excitations. In this study we extend the
spectroscopic method into imaging that enables screening
multiple samples at the same time. Furthermore, by
interleaving a number of saturation and readout periods
within the TR, a series of images with different
saturation times can be acquired allowing quantification
of the exchange rates using variable saturation time
(QUEST) approach. Since only two images are needed, the
method reduces time required to acquire Z-spectra and
enables high throughput screening of CEST contrast
agents.
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