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Abstract #3153

High Throughput Screening of Contrast Agents by Ultrafast CEST Imaging

Xiang Xu 1,2 , Jiadi Xu 1,2 , Nirbhay N. Yadav 1,2 , Craig K. Jones 1,2 , Michael T. McMahon 1,2 , Alexej Jerschow 3 , and Peter C. M. van Zijl 1,2

1 Radiology Department, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 3 Chemistry Department, New York University, New York, NY, United States

Recently we reported an ultrafast method to obtain a Z-spectrum over a large range of frequency offsets from only two signal excitations. In this study we extend the spectroscopic method into imaging that enables screening multiple samples at the same time. Furthermore, by interleaving a number of saturation and readout periods within the TR, a series of images with different saturation times can be acquired allowing quantification of the exchange rates using variable saturation time (QUEST) approach. Since only two images are needed, the method reduces time required to acquire Z-spectra and enables high throughput screening of CEST contrast agents.

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