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Abstract #3074

Altered resting-state functional connectivity of cerebellum in Parkinson's disease

Hu Liu 1 , Guoguang Fan 1 , and Ke Xu 1

1 Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

An improved understanding of the cerebellum, especially the cerebello-thalamo-cortical (CTC) circuit in Parkinsons disease (PD)-related changes, is essential for a better understanding of the pathophysiology of the disorder. Previous study describes a relationship between the anterior lobe of the cerebellum and motor function, and between the posterior lobe and executive function. Using functional connectivity method we found increased functional connectivity of the cerebellar posterior lobe in the resting state. This alteration may play a compensatory role in cognitive or executive functions of PD patients.

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