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Abstract #3075

Altered resting-state functional connectivity of the insular system in chronic cocaine users

Yuzheng Hu 1 , Hong Gu 1 , Betty Jo Salmeron 1 , Xia Liang 1 , Elliot Stein 1 , and Yihong Yang 1

1 Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, Baltimore, MD, United States

Accumulative evidence has indicated the involvement of the insular system in drug addiction by its fundamental role in interoception. However, relationship between the interoception, neurobiological measures of insula and addiction behaviors remains unclear. To address this question, the current study employed Toronto Alexithymia Scale and resting-state functional connectivity method to cocaine dependents and well-matched controls. Altered insula-cingulate and insula-frontal functional connectivity, abnormal alexithymic trait and dis-association between insula-cingulate functional connectivity and alexithymia were observed in chronic cocaine users. These findings may shield insight on the neurobiological bases of drug addiction.

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