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Abstract #3048

Postherpetic neuralgia alters small-world brain functional networks

Yue Zhang 1 , Jing Liu 2 , Longchuan Li 3 , Minyi Du 4 , Wenxue Fang 4 , Dongxin Wang 4 , Xuexiang Jiang 2 , Xiaoping Hu 3 , Jue Zhang 1 , Xiaoying Wang 2 , and Jing Fang 1

1 College of Engineering, Peking University, Beijing, Beijing, China, 2 Department of Radiology, Peking University First Hospital, Beijing, Beijing, China, 3 Biomedical Imaging Technology Center, Department of Biomedical Engineering, Georgia Institute of Technology / Emory University, Atlanta, Georgia, United States, 4 Department of Anesthesiology, Peking University First Hospital, Beijing, Beijing, China

Understanding the effect of postherpetic neuralgia (PHN) pain on brain activity is important for clinic strategies. This is the first study, to our knowledge, to relate PHN pain to small-world properties of brain functional networks. Functional magnetic resonance imaging was used to construct brain functional networks during the resting state. Sixteen patients with PHN pain and sixteen age-matched controls were analyzed (8 males, 8 females for both groups). Decreased local efficiency for PHN in comparison with the healthy controls was found. Moreover, regional nodal efficiency was found to be profoundly affected for PHN.

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