Abstract #3047
Hub identification in dynamic resting-state functional connectivity of the default mode network
Soroosh Afyouni 1,2 , Joanne R Hale 2 , Stephen D Mayhew 2 , Theodoros N Arvanitis 1,3 , and Andrew P Bagshaw 2
1
Institute of Digital Healthcare, WMG,
University of Warwick, Coventry, West Midlands, United
Kingdom,
2
School
of Psychology, University of Birmingham, Birmingham,
West Midlands, United Kingdom,
3
Birmingham
Childrens Hospital NHS Foundation Trust, Birmingham,
West Midlands, United Kingdom
This study investigated the dynamics of hub regions
within the default mode network (DMN) of the human
brain. Volunteers underwent a 15-minute fMRI scan and
dynamic functional connectivity (FC) was calculated
using a 240s sliding window within eight DMN regions of
interest. To identify hub regions, both binarized and
weighted degree and betweenness centrality metrics were
calculated from adjacency matrices obtained using
regularized inverse covariance and integrated over a
range of thresholds. The posterior cingulate cortex had
the highest centrality across the entire scan,
consistent with studies using stationary FC which have
identified it as the primary DMN hub.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
