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Abstract #3047

Hub identification in dynamic resting-state functional connectivity of the default mode network

Soroosh Afyouni 1,2 , Joanne R Hale 2 , Stephen D Mayhew 2 , Theodoros N Arvanitis 1,3 , and Andrew P Bagshaw 2

1 Institute of Digital Healthcare, WMG, University of Warwick, Coventry, West Midlands, United Kingdom, 2 School of Psychology, University of Birmingham, Birmingham, West Midlands, United Kingdom, 3 Birmingham Childrens Hospital NHS Foundation Trust, Birmingham, West Midlands, United Kingdom

This study investigated the dynamics of hub regions within the default mode network (DMN) of the human brain. Volunteers underwent a 15-minute fMRI scan and dynamic functional connectivity (FC) was calculated using a 240s sliding window within eight DMN regions of interest. To identify hub regions, both binarized and weighted degree and betweenness centrality metrics were calculated from adjacency matrices obtained using regularized inverse covariance and integrated over a range of thresholds. The posterior cingulate cortex had the highest centrality across the entire scan, consistent with studies using stationary FC which have identified it as the primary DMN hub.

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