Abstract #3015
FUNCTIONAL CORRELATES OF IMPAIRED WORKING MEMORY IN MS PATIENTS: A MULTICENTRE STUDY
Paola Valsasina 1 , Maria A. Rocca 1 , Alvino Bisecco 1 , Khaled Abdel-Aziz 2 , Frederik Barkhof 3 , Christian Enzinger 4 , Franz Fazekas 5 , Antonio Gallo 6 , Hanneke Hulst 3 , Xavier Montalban 7 , Nils Muhlert 2 , Gianna C Riccitelli 1 , Alex Rovira 8 , Gioacchino Tedeschi 6 , Giancarlo Comi 9 , and Massimo Filippi 1
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
MI, Italy,
2
Dept.
Brain Repair and Rehabilitation, Institute of Neurology,
UCL, London, GB, United Kingdom,
3
Department
of Radiology, Free University Medical Centre, Amsterdam,
NL, Netherlands,
4
Division
of Neuroradiology, Medical University of Graz, Graz, AT,
Austria,
5
Department
of Neurology, Medical University of Graz, Graz, AT,
Austria,
6
Department
of Medical, Surgical, Neurological, Metabolic and Aging
Sciences, Second University of Naples, Naples, NA,
Italy,
7
Department
of Neurology-Neuroimmunology, Vall dHebron University
Hospital, Barcelona, CT, Spain,
8
Department
of Radiology, Vall dHebron University Hospital,
Barcelona, CT, Spain,
9
Department
of Neurology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy
Functional MRI (fMRI) during a n-Back task was applied
in a multicenter study to assess the functional
correlates of frontal lobe dysfunction in multiple
sclerosis (MS) patients with/without cognitive
impairment. Twenty MS patients (47%) were cognitively
impaired (CI). With increasing n-back load, CI patients
had a distributed reduced fMRI activity (in bilateral
parietal and frontal regions, and bilateral insula) and
fMRI deactivations (in the bilateral precuneus,
posterior cingulate cortex and parahyppocampal gyrus)
compared to healthy controls and cognitively preserved
patients. Preserved fMRI activity of the frontal lobe is
associated with a better cognitive profile in MS.
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