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Abstract #3016

The interaction of APOE genotype by Age in amnestic mild cognitive impairment: a voxel-based morphometric study

Jiu Chen 1 and Zhi-jun Zhang 1

1 Neurologic Department, Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, nanjing, jiangsu, China

The study showed that amnestic mild cognitive impairment (aMCI) had the deficits of gray matter (GM) volume on the network of cerebellum-limbic system, and suggests an apolipoprotein E (APOE)-specific effect of age with GM volume on the occipito-insula-frontal neural circuit. Moreover, the results suggest that GM deficits could be accelerated by the combined effect of the aging process and the presence of the APOE 4 allele. Conversely, the APOE 2 possibly reflects a protective morphometric main effect, which increases with age in aMCI. The relationship of GM alterations with neuropsychological test supported that GM atrophy was the basis of cognitive impairment in aMCI.

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