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Abstract #3014

Working memory deficit in children treated for cerebellar medullobastoma: An fMRI study

Duc Ha Hoang 1 , Anne Pagnier 2 , Emilie Cousin 3 , Karine Guichardet 2 , Isabelle Schiff 2 , Fanny Dubois-Teklali 2 , and Alexandre Krainik 4

1 Grenoble Institute of Neurosciences, Grenoble, France, 2 Department of Pediatrics - Grenoble University Hospital, Grenoble, France, 3 Laboratoratory of Psychology and Neurocognition - University Pierre Mendès, Grenoble, France, 4 Department of Neuroradiology and MRI - Grenoble University Hospital, Grenoble, France

Survivors with medulloblastoma demonstrated working memory (WM) deficit, leading to an impairment of school performance. The purpose is to describe the cerebellar involvement in specific cognitive deficits observed in children with medulloblastoma • 9 healthy volunteers children and 5 patients with cerebellar medulloblastoma. Using BOLD fMRI, SPM8 • 4/5 patients had a WM deficit following a resection of left posterior cerebellar lobe (CrusI/II, lobule VIIb/VIII) and inferior vermis; the only patient without WM deficit was the only one without cerebellar hemispheric lesion. BOLD activations were found in the left posterior cerebellar lobe • The left posterior cerebellar lobe may involve the visuospatial WM

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