Abstract #3013
Effect of temporal lobe epilepsy on language function revealed by fMRI
Kapil Chaudhary 1 , S SENTHIL KUMARAN 2 , Poodipedi Sarat Chandra 3 , and Manjari Tripathi 1
1
Neurology, All India Institute of Medical
Science, New Delhi, Delhi, India,
2
Department
of NMR, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, New
Delhi, Delhi, India,
3
Neurosurgery, All India
Institute of Medical Science, New Delhi, Delhi, India
Hippocampal sclerosis (HS) and malformations of cortical
development (MCDs) are most common structural
abnormalities in patients with chronic intractable
epilepsy. Chronic intractable epilepsy is common cause
of mesial temporal sclerosis which can affect mesial
temporal structures and mesial frontal region associated
language areas. Our result has suggested that LTLE
patients showed atypical language reorganization in
comparison to RTLE and ETLE group after surgery. In this
study we used maximum componants of language (semantic,
semantic decision task, lexical and comprehension
language). Study is helpful for determine effectiveness
of fMRI language paradigm, surgery planning, language
reorganisation (Pre & post surgery) in LTLE, RTLE and
ETLE patients.
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