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Abstract #3013

Effect of temporal lobe epilepsy on language function revealed by fMRI

Kapil Chaudhary 1 , S SENTHIL KUMARAN 2 , Poodipedi Sarat Chandra 3 , and Manjari Tripathi 1

1 Neurology, All India Institute of Medical Science, New Delhi, Delhi, India, 2 Department of NMR, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, New Delhi, Delhi, India, 3 Neurosurgery, All India Institute of Medical Science, New Delhi, Delhi, India

Hippocampal sclerosis (HS) and malformations of cortical development (MCDs) are most common structural abnormalities in patients with chronic intractable epilepsy. Chronic intractable epilepsy is common cause of mesial temporal sclerosis which can affect mesial temporal structures and mesial frontal region associated language areas. Our result has suggested that LTLE patients showed atypical language reorganization in comparison to RTLE and ETLE group after surgery. In this study we used maximum componants of language (semantic, semantic decision task, lexical and comprehension language). Study is helpful for determine effectiveness of fMRI language paradigm, surgery planning, language reorganisation (Pre & post surgery) in LTLE, RTLE and ETLE patients.

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