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Abstract #2993

Robust BOLD activation outside visual and motor cortex during a simple visual and motor task detected by whole-brain T2-prepared spin-echo (SE) BOLD fMRI at 7T

Jun Hua 1,2 , James J Pekar 1,2 , Peter C.M. van Zijl 1,2 , Qin Qin 1,2 , Craig K Jones 1,2 , and Jeffrey M Yau 3

1 The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3 Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Localized BOLD activations in visual/motor cortex are typically observed during visual/motor tasks. Recent studies show that BOLD activities can be detected in many other regions during such tasks. Here, we performed whole-brain fMRI experiments with simultaneous flashing-checkerboard and finger-tapping using GRE-EPI, SE-EPI and T2-prepared SE-BOLD fMRI. Robust activations outside visual/motor cortex can be detected by T2prep-BOLD, but not GRE/SE-EPI. CNR in these regions was greater in T2prep-BOLD, mainly due to much reduced dropout and distortion compared to EPI. This implies that important information might be missed in these regions with GRE/SE-EPI, especially for cognitive fMRI studies with sophisticated tasks.

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