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Abstract #2994

Longitudinal Measurement of CBF and CBV Using Arterial Spin Labeling and Steady State Contrast Enhancement fMRI

Iris Asllani 1,2 , Shazia Dharssi 3 , Richard P Sloan 3 , and Scott A Small 3

1 Biomedical Engineering, Rochester Institute of Technology, Rochester, NY, United States, 2 Rochester Center for Brain Imaging, University of Rochester, NY, United States, 3 Columbia University, NY, United States

To study the effects of normal aging and disease progression on the brain function, we need to develop fMRI methods that provide both quantifiable and reliable measures of metabolism over the time-scales involved in these processes. To this end, we have developed an fMRI method that combines ASL perfusion fMRI with steady state contrast enhanced (SSCE) fMRI to image CBF and CBV, concomitantly. Here we report on the test-retest reliability of this method by comparing CBF and CBV images acquired on older subjects at two time-points, 90 days apart.

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