Meeting Banner
Abstract #2954

Whole body Radiation Induced Early Delayed Changes in Mice Brain: Behavioral Evaluation and 1H MRS Study

Mamta Aryabhushan Gupta 1 , Poonam Rana 1 , Seenu Haridas 2 , Kailash Manda 2 , BS Hemanth Kumar 1 , and Subash Khushu 1

1 NMR Research Centre, INMAS, DRDO, Delhi, delhi, India, 2 Division of Radiation Biosciences, INMAS, DRDO, Delhi, delhi, India

Effect of whole body radiation exposure on central nervous system has not been explored much in brain. In the present study we investigate behavior evaluation and 1H MRS based early delayed cognitive and neurometabolite changes in hippocampus at 3 months following 5Gy whole body radiation exposure. Behavioral studies showed locomotory and discrimination ratio impaired in irradiated group.1H MRS revealed significant decrease in Glutamine and significant increase in myo inositol in irradiated group compared to controls. Our results demonstrate whole body radiation induced cognitive dysfunction and metabolic impairment at 3 months post whole body irradiation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here