Abstract #2953
Metabolite Proton T2 Relaxation Times in the Rat Brain in Vivo at 17.2 Tesla
Alfredo Liubomir Lopez Kolkovsky 1 , Boucif Djemai 1 , and Fawzi Boumezbeur 1
1
CEA/Saclay/Neurospin, Commissariat a
l'Energie Atomique, Gif-sur-yvette, Essonne, France
At ultra-high magnetic fields such as 17.2 T, it is
crucial to establish T
1
and
T
2
relaxation
times in order to optimize MRS acquisition parameters
and to achieve proper metabolite concentration
quantification. In this study we present measurements of
T
2
relaxation
times of more than 18 metabolites and macromolecules in
the rat brain
in
vivo
at 17.2T. J-modulation of major brain
metabolites such as glutamate and myo-inositol was
adequately accounted for by our spin simulations.
Compared to T
2
values
measured at lower magnetic fields, our values are
shorter which is consistent with the established
field-dependence of T
2
to
increased microscopic susceptibility gradients as B
0
increases.
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